unilad homepage
unilad homepage
    • News
      • UK News
      • US News
      • World News
      • Crime
      • Health
      • Money
      • Sport
      • Travel
    • Music
    • Technology
    • Film and TV
      • News
      • DC Comics
      • Disney
      • Marvel
      • Netflix
    • Celebrity
    • Politics
    • Advertise
    • Terms
    • Privacy & Cookies
    • LADbible Group
    • LADbible
    • SPORTbible
    • GAMINGbible
    • Tyla
    • UNILAD Tech
    • FOODbible
    • License Our Content
    • About Us & Contact
    • Jobs
    • Latest
    • Archive
    • Topics A-Z
    • Authors
    Facebook
    Instagram
    X
    Threads
    TikTok
    YouTube
    Submit Your Content
    Christina Applegate details 'subtle' first symptom she noticed as she labels MS 'worst thing she's ever gone through'
    Home>News>Health
    Published 19:18 9 May 2025 GMT+1

    Christina Applegate details 'subtle' first symptom she noticed as she labels MS 'worst thing she's ever gone through'

    Christina was diagnosed with MS in 2021

    Lucy Devine

    Lucy Devine

    google discoverFollow us on Google Discover
    Featured Image Credit: YouTube/TeamCoco

    Topics: Celebrity, Christina Applegate, Health, Podcast

    Lucy Devine
    Lucy Devine

    Advert

    Advert

    Advert

    Christina Applegate has spoken about the first subtle symptom of multiple sclerosis (MS) she experienced before her diagnosis.

    MS is a disease that causes the breakdown of the protective covering (myelin) of the nerves, causing a miscommunication between the brain and the rest of the body and leading to numbness, weakness, vision problems, and mobility issues.

    Applegate, 53, was diagnosed with the health condition in 2021, and has been extremely open about what it's like living with MS ever since.

    Recently, she appeared on the Conan O'Brien Needs a Friend podcast with Jamie-Lynn Sigler, where she discussed the condition and the first 'subtle' signs she experienced.

    Advert

    "It was January 2021, my mom had just been diagnosed with cancer for the third time, there was some other stuff going on in my life, it was a really stressful and traumatic time," said Christina.

    "My toes started to feel numb, just my toes a little bit. I was still hiking, I was still playing tennis but my toes weren't feeling right.

    "Eventually, over those months, it grew from my toes, to my ankles, to my knees down is a whole other ball game. I was losing balance, the pain was extraordinary. When I say numb, it was numb but it hurts."

    Christina explained that it was actually Selma Blair who told her to go and see a neurologist.

    Christina opened up on her symptoms (Gilbert Flores/Variety via Getty Images)
    Christina opened up on her symptoms (Gilbert Flores/Variety via Getty Images)

    According to Mayo Clinic, common symptoms of MS can include:

    • Numbness and tingling
    • Electric shock sensations
    • Lack of co-ordination
    • Mobility issues
    • Weakness
    • Partial or complete loss of vision
    • Double vision
    • Blurry vision
    • Dizziness or vertigo
    • Trouble with sexual, bowel and bladder function
    • Fatigue
    • Slurred speech
    • Issues with memory
    • Mood changes
    Christina spoke about the subtle sign she noticed (Phillip Faraone/Getty Images)
    Christina spoke about the subtle sign she noticed (Phillip Faraone/Getty Images)

    Christina explained that she was having a 'bad symptomatic day' while interviewing for the podcast, revealing that she has some days that are worse than others.

    "If people saw what my life was like on the daily, they wouldn't be able to do it. Because I can sometimes not do it. It's really, really hard," she said.

    "I don't really leave the house anymore.

    "... The first thing that I hear from people is 'how did you get it'? Meaning I must have done something wrong in my life to have this disease, I did it to myself. It's like I had breast cancer as well so, oh you must have done something.

    "That stigma, I'm used to it now but it was so hard to swallow for a while because why the f**k would you think that I would do something to have this, because this is the worst thing I've ever had in my life.

    "It's the worst thing I've ever gone through."

    Choose your content:

    an hour ago
    2 hours ago
    3 hours ago
    • Andres Gutierrez/Anadolu via Getty Images
      an hour ago

      Tourist hotspot hits back at claims it caused hantavirus after 'patient zero' visit

      Health experts tracing the source of the deadly hantavirus outbreak believe 'patient zero' may have travelled from a popular tourist hotspot

      News
    • Gilbert Flores/Variety via Getty Images
      an hour ago

      Adult star Maitland Ward reveals exactly what is wrong with Sydney Sweeney's controversial Euphoria baby scene

      The latest season of Euphoria sees Sweeney's character taking up adult work

      Film & TV
    • Andres Gutierrez/Anadolu via Getty Images
      2 hours ago

      CDC addresses hantavirus pandemic fears after 'patient zero' identified

      Fears that hantavirus could cause another disruptive pandemic has led world health experts to address the public

      News
    • Andrew Harnik/Getty Images
      3 hours ago

      Trump calls Iran's response to peace plan 'totally unacceptable' after reading it

      The US-Israeli war with Iran shows no sign of ending, with Donald Trump rejecting Tehran's latest attempt at neogtiating

      News
    • Christina Applegate hospitalized with pain that left her 'screaming' amid MS diagnosis
    • Christina Applegate makes heartbreaking admission about her health in candid update amid MS diagnosis
    • Christina Applegate explains surprising reason she has named body part after Meghan Markle following MS diagnosis
    • Christina Applegate reveals Will Ferrell and Adam McKay gave up part of Anchorman salary after she received 'offensive' offer