
Joe Manganiello is sharing more insight into his mystery illness, which left him 'dealing with excruciating bouts of chronic pain.'
The Magic Mike star, 49, first opened up about his seven-year illness earlier this year, when the synopsis to his memoir, Bloodlines, was released.
Here, it was made known that the actor had dealt with 'a cascade of autoimmune-related illnesses that attacked his skin, thyroid, eyes, lungs, and digestive system.' It was also revealed that the Hollywood icon had a 'a life-saving organ amputation.'
Now, Manganiello has taken to his Instagram to share pictures from the amputation of his large intestine.
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In the first photo, the Spider-Man star could be seen sitting up in a hospital room, surrounded by machines.
Describing the photo, he penned: "In the days following the amputation of my large intestine, my weight began to plummet."
Following the surgery, he confirmed he had lost 60 lbs in just two weeks.

"If you zoom in, you can see the top of my first ostomy bag creeping up over the sheets," he wrote.
Manganiello then posted a photo of his abdomen, following 'the reconnection/take down surgery or anastomosis, in which my ostomy bag was removed and what was left of my digestive tract was reconnected.'
In the third and final image, the actor posted a close-up photo of himself with a rash over his face.
"An example of the multitude of skin conditions I was plagued with during the seven years I was sick," he wrote.
"My skin, an immune organ, was stricken with just about every condition known to man, usually in combination."
Manganiello has now 'come out the other end,' he revealed in a recent interview.

“There are remnants from the surgeries and procedures that I have to live with, but I don’t complain about them because life is manageable,” he told Entertainment Weekly.
“I weathered that storm and came out of the other end, and I say it in the book, but life began again for me."
The True Blood star added that he was 'healthy, happy, and peaceful,' after his symptoms stopped three years ago.
Manganiello was married to his ex, Sofía Vergara during his illness. The two went their separate ways in 2023, although the actor said they could have 'possibly' stayed together if it wasn't for his illness.
When asked the question on SiriusXM’s Radio Andy, he simply said: "Possibly."
“It’s heartbreaking when you look at these two people with life ahead of them, but for us, we didn’t know what was ahead,” he added. "I felt guilty for a long time."
He is now engaged to Caitlin O'Connor.