• News
  • Film and TV
  • Music
  • Tech
  • Features
  • Celebrity
  • Politics
  • Weird
  • Community
  • Advertise
  • Terms
  • Privacy & Cookies
  • LADbible Group
  • LADbible
  • SPORTbible
  • GAMINGbible
  • Tyla
  • UNILAD Tech
  • FOODbible
  • License Our Content
  • About Us & Contact
  • Jobs
  • Latest
  • Topics A-Z
  • Authors
Facebook
Instagram
X
Threads
TikTok
YouTube
Submit Your Content
Christina Applegate opens up about being hospitalized over 30 times with ‘unimaginable’ pain following MS diagnosis

Home> Celebrity> News

Published 16:02 20 Mar 2025 GMT

Christina Applegate opens up about being hospitalized over 30 times with ‘unimaginable’ pain following MS diagnosis

The Dead To Me actor was diagnosed with MS in 2021 and has since spoken candidly

Emily Brown

Emily Brown

Christina Applegate got candid about her experience with multiple sclerosis as she opened up about her diagnosis in a new podcast episode.

The Dead To Me actor first revealed her MS diagnosis in 2021, and has since gone on to speak openly about how she came to learn she had the condition, which affects both the brain and spinal cord.

For Applegate, the initial symptoms were as simple as 'tingling on [her] toes', and within just a few months, she was being brought to set in a wheelchair as she struggled to walk.

In the years since her diagnosis, Applegate has consistently had to deal with the effects of health issues in almost every aspect of her life.

Advert

Christina Applegate was diagnosed with MS in 2021 (Gregg DeGuire/Getty Images for Turner)
Christina Applegate was diagnosed with MS in 2021 (Gregg DeGuire/Getty Images for Turner)

She spoke in more detail about the kind of situations she's experienced while marking the one-year anniversary of her MesSy podcast, when a listener wrote in to share experiences of their own.

The listener admitted they were 'throwing up and having diarrhea every single day' - symptoms which Applegate said she's very familiar with, even though doctors have claimed they're unrelated to her MS.

The actor said: "This is really important because for three years, since I was diagnosed, I’ve been in the hospital upwards of 30 times from throwing up and diarrhea and pain that is unimaginable."

Advert

Applegate said she has experienced 'unimaginable pain' (VALERIE MACON/AFP via Getty Images)
Applegate said she has experienced 'unimaginable pain' (VALERIE MACON/AFP via Getty Images)

Applegate went on to say doctors had done 'every test known to man' on her, from putting 'so much radiation' in her body to carrying out CT scans and 'everything else'.

She continued: “Now, maybe this isn’t what’s happening, but I’m just gonna tell you this: Talk to your doctor about motility issues, OK? Because one of the things with MS is that it slows down our organs — not completely, but there is a slowing of the function of your organs."

Not afraid of getting into specifics, Applegate went on: “I’m gonna be really honest, if I have to poop, I puke. And when I puke, I get all the pain, and then all the things happen.”

Advert

She dubbed the response as the 'fight club', saying: “So, there’s this really horrible argument. It’s like everyone’s fighting with each other.”

Applegate has sought to have a 'big conversation' with her medical team about the symptoms she's experienced; an argument she's attempted to back by going in for a recent colonoscopy.

“There’s gotta be a correlation here,” she said.

Among the symptoms of MS include numbness, weakness, trouble walking and vision changes.

Featured Image Credit: Gilbert Flores/Variety via Getty Images

Topics: Christina Applegate, Health, Podcast

Emily Brown
Emily Brown

Emily Brown is UNILAD Editorial Lead at LADbible Group. She first began delivering news when she was just 11 years old - with a paper route - before graduating with a BA Hons in English Language in the Media from Lancaster University. Emily joined UNILAD in 2018 to cover breaking news, trending stories and longer form features. She went on to become Community Desk Lead, commissioning and writing human interest stories from across the globe, before moving to the role of Editorial Lead. Emily now works alongside the UNILAD Editor to ensure the page delivers accurate, interesting and high quality content.

Advert

Advert

Advert

Choose your content:

15 hours ago
19 hours ago
a day ago
  • Chris Haston/WBTV via Getty Images
    15 hours ago

    Cardi B confirms she’s pregnant with her fourth child after rumors sent fans into frenzy

    The Bardi Gang have been in a frenzy for weeks

    Celebrity
  • Gilbert Flores/Variety via Getty Images/JOSH EDELSON/AFP via Getty Images
    19 hours ago

    Michael Keaton sparks outrage with controversial Charlie Kirk assassination comments

    The actor has come under fire for his comments about Charlie Kirk this week

    Celebrity
  • YouTube/Breakfast Club
    a day ago

    Nick Cannon explains why having 12 children was a response to trauma

    The TV & comedy star reflects on past struggles

    Celebrity
  • Getty Images/Gilbert Flores
    a day ago

    Jamie Lee Curtis makes honest Charlie Kirk remark after 'disagreeing with him on everything'

    The actress fought through tears to make the remarks on Marc Maron's WTF podcast

    Celebrity
  • Christina Applegate shares devastating reason she gets up in the morning following MS diagnosis
  • Christina Applegate shares five ‘weird’ symptoms she ignored before MS diagnosis
  • Christina Applegate reveals how her MS diagnosis has ‘broken’ her 14-year-old daughter Sadie
  • Christina Applegate addresses her ‘I don’t enjoy living’ comment amid MS battle