An interview from The David Letterman Show with Jennifer Aniston has resurfaced and it has made fans seriously uncomfortable.

While the segment may have been accepted at the time, fans have now been reacting angrily to the host’s unhygienic antics.

The bizarre (and let’s face it, creepy) moment happened while Aniston was promoting her new rom-com, The Object of My Affection.

Instead, the host uses the opportunity to make Aniston feel as uncomfortable as possible, with the then-51-year-old getting as close as possible to the then-29-year-old actor.

Edging towards her face, he tells her: "Forgive me if this is rude, I just want to try one thing."

It’s then that the veteran talk show host put a strand of her hair in her mouth, with the actor desperately trying to laugh off the moment as he slowly pulls away (gross!).

Many users have agreed and pointed out just how unacceptable Letterman's behaviour was, especially considering that Aniston was 22 years his junior.

“These Letterman clips have been making the rounds online - and they are disturbing to say the least,” wrote one former fan, “How was this even acceptable baffles the mind and conscience.”

Others agreed, with another adding: “Misogyny at its finest. I knew a Letterman was a creep (and not very funny) back in the day but I’m ashamed to say I never noticed or commented on this unacceptable behaviour.”

One tweet even suggested that viewers had always been aware of how wrong the clip was, saying: “That was horrible, she clearly didn't want it or like it and the audience saw that.”