Ellen called out after making Penelope Cruz play 'uncomfortable' kissing game on TV show

Ellen DeGeneres has once again found herself in hot water after getting Penelope Cruz to play an 'uncomfortable' kissing game on her show.

The host, 64, shared a clip of the segment with the actress, 48, on Instagram and to say it didn't go down well would be an understatement.

Ellen captioned the clip: "Quizzing @penelopecruzoficial on all of her male on-screen kisses based on only seeing their lips!"

In the segment, Ellen can be seen reminding Cruz that she has kissed a lot of men in her time as an actress, she then decides to challenge the actress to identify them based on their lips alone.

The actress then appears to uncomfortably go along with it, breaking a smile only when she correctly guesses that the first celeb in the lineup is Matt Damon.

Things only get more awkward from there as the actress correctly guessed who each celebrity was, ending with Scarlett Johansson's famously full pout.

As noted by Ellen, the pair locked lips in the 2008 romantic comedy Vicky Cristina Barcelona.

The unusual choice of a game and Cruz's reaction to it went far form unnoticed when Ellen posted the segment to her Instagram account.

The most popular reaction simply read: "She was NOT having it lol."

"None of the guys have any lips," joked a second with a laughing emoji while a third wrote: "She looks p**sed."

"She looks pretty uncomfortable with the game," remarked a fifth with a sad face.

Instagram / theellenshow

[I'm] thinking she found that slightly uncomfortable," remarked a sixth. "Not many women want to brag about all the men they've kissed."

"The show is over..." slammed another.

Meanwhile, another viewer who enjoyed the clip more than most, revealed: "Haven't kissed any of them and yet I answered all correctly… daaaaa!"

While Cruz might have kissed some of Hollywood's most desirable people, she opened up about having imposter syndrome in an interview earlier this year.

She said that despite working with celebrated filmmaker Pedro Almodóvar for the seventh time in Parallel Mothers, she was still concerned that he was going to suddenly fire her from the project.

"What's funny is that, even though he's one of my best friends, during the first few days of shooting, I'm so scared of him [laughs]," she admitted to Vogue. "I'm like, 'What if he fires me?' I have imposter syndrome. Why do I still feel this way? It’s respect."

Parallel Mothers was released in October of last year.