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Shocking findings of new trial on Ozempic alternative pushes it closer to approval

Home> News> Health

Published 19:39 25 Apr 2025 GMT+1

Shocking findings of new trial on Ozempic alternative pushes it closer to approval

It could be a game-changer

Ellie Kemp

Ellie Kemp

A new weight loss drug that's being trialled as a daily pill and could rival Ozempic has delivered some astonishing results.

One in eight Americans have reportedly tried GLP-1 drugs like Ozempic - a type of medication aimed at helping those with type 2 diabetes. Although some have said they come with some unpleasant side effects.

Ozempic isn't FDA approved to help with weight loss, but other drugs containing GLP-1 receptor agonists - like semaglutide (Wegovy) and liraglutide (Saxenda) - are.

But now pharma giants Eli Lilly might have just made a major breakthrough on diabetes and weight loss, in the form of a pill.

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Called orforglipron, it's taken orally once a day.

Similar to other Ozempic-like drugs, the pill is part of the GLP-1 receptor family, which help regulate blood sugar and appetite.

There is a GLP-1 pill on the market now called Rybelsus, however it has strict food-timing rules and could cause some strong nausea.

However, Orforglipron doesn't need to be taken with food - or even water, as Very Well Health reports.

Plus, it's better than jabbing yourself with a needle once a week.

Although it's the results from medical trials so far that have been eye-opening, yielding some incredible results.

In a 40-week trial, Orforglipron was found to have lowered peoples' A1C - a key blood sugar marker - by up to 1.6 percent.

Even more astonishingly, two-thirds of people on the highest dose, 36 milligrams, ended up with blood sugar levels below the diabetes threshold.

All thanks to popping a once-a-day tablet.

Researchers also looked into weight loss, and participants were found to have lost an average of eight percent of their body weight, which was around 16 pounds.

This was found in those who'd taken the pill at its highest dose.

Ozempic has to be injected weekly (Iuliia Burmistrova/Getty Images)
Ozempic has to be injected weekly (Iuliia Burmistrova/Getty Images)

The company said the participants had not yet reached a weight loss plateau by the time the study ended, and it's possible more weight could've been lost had the trial continued.

Orforglipron does come with a few side effects, but they're mild and pretty common for GLP-1 medications, such as a bad stomach.

More importantly, it doesn't bring on any liver issues - which is a big deal since Pfizer just scrapped their own version of a GLP-1 pill over a potential liver injury.

So what’s next?

Eli Lilly is aiming for FDA approval to sell Orforglipron for weight loss later this year, and for diabetes by 2026.

Could this be the very drug to overtake Ozempic and other similar injectables on the market? It's sounding promising...

Featured Image Credit: Getty Images

Topics: Ozempic, Health

Ellie Kemp
Ellie Kemp

Ellie joined UNILAD in 2024, specialising in SEO and trending content. She moved from Reach PLC where she worked as a senior journalist at the UK’s largest regional news title, the Manchester Evening News. She also covered TV and entertainment for national brands including the Mirror, Star and Express. In her spare time, Ellie enjoys watching true crime documentaries and curating the perfect Spotify playlist.

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@EllieKempOnline

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