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Christina Applegate shares heartbreakingly honest admission about living with MS after revealing early symptoms

Home> Celebrity> News

Updated 14:01 6 May 2025 GMT+1Published 13:33 6 May 2025 GMT+1

Christina Applegate shares heartbreakingly honest admission about living with MS after revealing early symptoms

Christina Applegate was diagnosed with the progressive nerve disease in 2021

Niamh Shackleton

Niamh Shackleton

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Featured Image Credit: Getty Images/Emma McIntyre

Topics: Christina Applegate, Health, Celebrity, Podcast, News, Life

Niamh Shackleton
Niamh Shackleton

Niamh Shackleton is an experienced journalist for UNILAD, specialising in topics including mental health and showbiz, as well as anything Henry Cavill and cat related. She has previously worked for OK! Magazine, Caters and Kennedy.

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Christina Applegate had shared some insight into her life with multiple sclerosis (MS).

Applegate, 53, was diagnosed with the health condition in 2021 and has been extremely candid about what it's like living with MS ever since.

One particular thing the actress has been vocal about is the symptoms she experienced before her diagnosis.

Previously speaking to Good Morning America, Applegate revealed that one of the first things she noticed was a tingling sensation in her toes.

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"My symptoms had started in the early part of 2021, and it was, like, literally just tingling on my toes," she shared.

"And by the time we started shooting in the summer of that same year, I was being brought to set in a wheelchair. Like, I couldn’t walk that far."

Other symptoms she has experienced include muscle weakness, lack of balance, and sharp pains.

Now the Dead to Me star has lifted the lid on what her day to day life has been like of late and made a heartbreaking admission.

Speaking on a recent episode of Conan O'Brien's podcast, Conan O'Brien Needs a Friend, Applegate said: "If people saw what my life was like on the daily, they wouldn't they wouldn't be able to do it. Because I can sometimes not do it. It's really, really hard."

She added: "I don't really leave the house anymore."

Christina Applegate received her MS diagnosis in 2021 (Frazer Harrison/Getty Images)
Christina Applegate received her MS diagnosis in 2021 (Frazer Harrison/Getty Images)

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Applegate further shared that she's sometimes asked how she got the condition - something which remains unknown.

The Anchorman actress said that this type of question makes her feel like she 'must have done something wrong in my life to have this disease'.

Referencing to her 2008 cancer diagnosis, Applegate continued: "It's, like, I had breast cancer as well, so, 'Oh, you must have done something'.

"That stigma is - I'm used to it now, but it was for a while, like, was so hard to swallow because why the F would you think that I would do something to have this?"

What causes MS?

While there's no apparent cause of MS, there are risk factors that can increase your chances of developing the progressive condition.

According to Mayo Clinic, women are two to three times more likely than men to have relapsing-remitting MS. Also, if any of your family members have MS, you are at higher risk of developing the disease.

Other risk factors include climate, race, certain infections, and age.

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